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Mental Health Coming off Invega Sustenna (Paliperidone) v3

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Beautiful recovery story and an uplifting message. You're an inspiration to all of us on this forum, Koz.
 
How is everyone today?

For me: Days 40-45

Good
Mood seems to be improving a bit
Music is becoming slightly more enjoyable
I was able to get a library card to access my local public library
Visited with family, which went well for a couple of days but was bad on the last day

Bad
Major anhedonia (even though it is improving)
Sexual dysfunction
Fatigue
Diminished creativity
Diminished drive/passion for work
Issues with concentration and short term memory

I'm not going to lie. While things are getting slightly better each day (on average), I feel like a shell of myself. I've gone from functioning at a fairly high level (even w/ psychosis) to barely functioning at all. My emotions, my drive, and my passion are all severely diminished, as is my ability to retain information. I'm slowly starting to work on some projects of my own again (handwriting has been a challenge, but is getting better), but it is like working with a 25% version of myself.

This invega shot really represents the greatest challenge and I do not envy anyone who had to take more shots than I did (I just took the initial starter and loading dose).
 
Ii you only took the first dose then you might be completely be back to normal in 9 or 10 months which seems like a long time but it could be a lot longer
 
What do you guys think of Esketamine / Spravato? It is prescribed for treatment resistant depression and here is a video about it. Basically they just patented the ketamine microdosing idea. A lot of DIY users say K microdosing does wonders for their depression. This could also work for recovering AP users.

Most conventional antidepressants, such as Prozac, are selective serotonin reuptake inhibitors (SSRIs), which modulate levels of the chemical serotonin. Ketamine instead modulates glutamate, a different neurotransmitter, resulting in surges of the chemical BDNF, which stands for brain-derived neurotrophic factor. You can think of BDNF as a “fertilizer” for the brain. The end result: neurogenesis, the growth of new brain cells, and synaptogenesis, the formation of new connections between brain cells.
 
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does nasal spray effects invega to stay longer in system or not can anyone answer my question?
 
pilarti said:
does nasal spray effects invega to stay longer in system or not can anyone answer my question?
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Invega will leave the system, that not the problem.

Let's assume you had only one loading shot and most of it leaves your system within a year. Although Invega is out of your system, you brain chemistry, receptors, brain wiring (your neurological pathways) are no longer the same since you have been in this state for so long. Take action now or expect to be disappointed waiting for the pre-invega day that never comes.
 
bunnyrabbit528 said:
Invega will leave the system, that not the problem.

Let's assume you had only one loading shot and most of it leaves your system within a year. Although Invega is out of your system, you brain chemistry, receptors, brain wiring (your neurological pathways) are no longer the same since you have been in this state for so long. Take action now or expect to be disappointed waiting for the pre-invega day that never comes.
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& that’s what I’m afraid of. I’ve been off a year and almost 3 months with no improvements. Is there a way to speed up the process or somewhat detox it.
 
lifeline said:
& that’s what I’m afraid of. I’ve been off a year and almost 3 months with no improvements. Is there a way to speed up the process or somewhat detox it.
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First of all there is nothing related to AP detox that is proven to work. Second of all even if you had a bit of Invega left it will have negligible effect, just like any drug after everyday exposure there is a tolerance. It is not the Invega in your system that is causing you problems now, your brain is changed. The unknown road that is left is how to make your self the person you want to be. Neuroplasticity will work in your favour through joyful good habits; the only thing you can do is boost your mood out of that mental state so you can zone into doing things that make you feel good about yourself.
 
bunnyrabbit528 said:
First of all there is nothing related to AP detox that is proven to work. Second of all even if you had a bit of Invega left it will have negligible effect, just like any drug after everyday exposure there is a tolerance. It is not the Invega in your system that is causing you problems now, your brain is changed. The unknown road that is left is how to make your self the person you want to be. Neuroplasticity will work in your favour through joyful good habits; the only thing you can do is boost your mood out of that mental state so you can zone into doing things that make you feel good about yourself.
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Well I beg to differ. I feel exactly the same as when I received my third injection. Even if it’s not in my system anymore, I’m still suffering from the side effects. Like I feel no different no other way to explain it. I’m hoping to find a detox or something to speed up this process for me because this is ridiculous.
 
lifeline said:
Well I beg to differ. I feel exactly the same as when I received my third injection. Even if it’s not in my system anymore, I’m still suffering from the side effects. Like I feel no different no other way to explain it. I’m hoping to find a detox or something to speed up this process for me because this is ridiculous.
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What you are experiencing is not Invega still in your system. You have been changed after Invega. This is the new you. There is nothing to detox from. You are the result of Invega change that happened long time ago. Invega is not causing this now. You've been reset, brought down to the lowest level. You need to learn how to climb up now, there is nothing holding you down anymore.
 
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I think running 200meter lengths, cardio, exercise, etc will help. If you still feel off I think that’s a good sign your body is still trying to reset or find its footing. Help it reset with good nutrition, rest and cardio or exercise (circulation). I think running is a good place to start. There is more in you that wants to be you than not. As well you remember what it felt like to be great so the drug is losing it’s just not losing nicely. Also, if you can I would try water fasting as many days as possible. I did a 4 day water fast and the racing thoughts are gone. Still get anxiety from time to time, I go on a quick run and anxiety is gone. I run a lot and I feel better. It’s interesting how the hope disappears with this drug sometimes. Such evil, man doctors are such cold turkeys from hell if you ask me. The best of them are no help and owned by pharma. And the way they talk down to you.. ugh they must have it coming. The day when they face their own medical complications and the drugs do nothing but make it worse and they get to wonder about all the years they medicated people.
 
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bunnyrabbit528 said:
What you are experiencing is not Invega still in your system. You have been changed after Invega. This is the new you. There is nothing to detox from. You are the result of Invega change that happened long time ago. Invega is not causing this now. You've been reset, brought down to the lowest level. You need to learn how to climb up now, there is nothing holding you down anymore.
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How in the hell does that even make sense when I’m still not having thoughts, emotions, libido, struggling to sleep, can’t get hungry, can’t cry. These are all of the side effects I’m dealing with that started with taking this bullshit. You can’t tell me I’m back to myself when I had none of these issues before. I’m done conversing with you.
 
earwiggs said:
I think running 200meter lengths, cardio, exercise, etc will help. If you still feel off I think that’s a good sign your body is still trying to reset or find its footing. Help it reset with good nutrition, rest and cardio or exercise (circulation). I think running is a good place to start. There is more in you that wants to be you than not. As well you remember what it felt like to be great so the drug is losing it’s just not losing nicely. Also, if you can I would try water fasting as many days as possible. I did a 4 day water fast and the racing thoughts are gone. Still get anxiety from time to time, I go on a quick run and anxiety is gone. I run a lot and I feel better. It’s interesting how the hope disappears with this drug sometimes. Such evil, man doctors are such cold turkeys from hell if you ask me. The best of them are no help and owned by pharma. And the way they talk down to you.. ugh they must have it coming. The day when they face their own medical complications and the drugs do nothing but make it worse and they get to wonder about all the years they medicated people.
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Thanks for the advice I’ll def try that. I just need a relief at this point. It’s just scaring me that I’m dealing with the same side effects from the beginning even a year later.
 
lifeline said:
How in the hell does that even make sense when I’m still not having thoughts, emotions, libido, struggling to sleep, can’t get hungry, can’t cry. These are all of the side effects I’m dealing with that started with taking this bullshit. You can’t tell me I’m back to myself when I had none of these issues before. I’m done conversing with you.
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Don't twist my words. I never said you are back to yourself. I'm done conversing with you since you can't even understand in the lamest terms that you simply have been changed and no detox will help.
 
According to the study I posted earlier, the guy who had 4 shots in total and a BMI of >30, tested positive for paliperidone for 46 months. Paliperidone won't modify your DNA so any permanent effect on the brain is not caused by the drug. Invega is the most potent dopamine antagonist found on the market, so even a milligram of it would have a huge impact in a healthy persons cognition. I was prescribed risperidone before I had my injections. Risperidone metabolizes to paliperidone eventually. And if you compare the pharmacodynamics of both drugs, you will notice that paliperidone is almost twice as potent antagonist on the D2 receptors. I have never been so fucked up in my life physically or mentally than after taking the first 2 mg pill of risperidone. That would equal to less than 1 mg of paliperidone in terms of dopamine antagonism. From personal experience I can assure that even a small amount of this toxin can have a huge impact in you.

Dopamine receptor upregulation is a thing caused by invega though. You will start producing more dopamine receptors in response to the reduced amount dopamine available. Eventually your brain will become desensitized to dopamine, because of the high amount of receptors vs. the low amount of actual free dopamine. The dopamine stored inside your cells won't affect how you feel and it's basically inactive. Once the cell gets a signal from the presynaptic neuron, it will release dopamine in to the synapse, which the postsynaptic neurons will use in order to forward the signal. But since most of your receptors are antagonized, they will hardly release any dopamine, so the signal won't get through like it should. In theory you could counter this with a dopamine reuptake inhibitor such as Wellbutrin, or with uridine. Ask your doctor about this.

And as for the detoxes, I highly doubt that any detox product sold online will actually speed up the removal of paliperidone. If you can find a detox product which is proven to speed up fat metabolism, then that could potentially speed up the removal of it from the body, but not from the brain. A P-gp inducer will help to get rid of it from the brain aswell, at least in theory. I'm still waiting for my SJW to arrive so I can test this theory out. I was planning to get myself tested for the amount of paliperidone found in urine before and after consuming SJW to actually see if it has an effect. Technically the levels of paliperidone found in urine should rise after you consume SJW, at least at first, so that's what I'm hoping to see.
 
It has been proven and tested that antipsychotic drugs can change DNA. However, I did not intend to touch on this subject, simply now stating a well researched fact.
 
I'm going to take a break from this forum. I think the constant negativity has a reinforcing effect and a lot of people haven't mentally given themselves a chance to recover. I'll come back to let you guys know when I'm fully recovered, but until then, I think it's better to stay off of here.
 
does cough syrop or nasal spray effects invega or does it not can anyone answer my question plss?
 
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